Fibrillary glomerulopathy and DNAJB9 immunohistochemistry: case report and literature review

Fibrillary glomerulopathy represents an uncommon glomerular disease of organised deposits that is diagnosed in 0.5–1% native renal biopsies. It was first reported by Rosenmann and Eliakim 1977 as a with material very similar to amyloid did not stain Congo red. Until recently, this entity based on finding from histology electron microscopy. In the last few years, it has been shown identification heat-shock protein DNAJB9 immunostaining within these reliable tool diagnosis fibrillary glomerulopathy.1,2 This case 69-year-old female features proteinuria, intermittent low grade microscopic haematuria eGFR 62. On there significant mesangial predominant deposition PAS positive silver negative material, demonstrated IgG dominant immunostaining. Electron microscopy later confirmed presence randomly arranged fibrils demonstrating diameter range 14 23 nm. means for review current literature regarding use marker glomerulopathy. References 1. Andeen NK, Troxell ML, Riazy M, et al. glomerulonephritis: clinicopathologic atypical cases multi-institutional cohort. CJASN 2019; 14: 1741–1750. 2. Nasr SH, Vrana JA, Dasari S. specific immunohistochemical glomerulonephritis. Kidney Int Rep 2017; 3: 56–64.